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Etiology And Pathogenesis Of Organic Phosphorus Pesticide Poisoning
Sep 28, 2017

Organic Phosphorus pesticide poisoning is a common cause of toxic poisoning, use of poisoning and life poisoning. The main reason for strict poisoning is in the process of organic phosphorus pesticide production is not strict, pesticides absorbed through the skin and respiratory tract caused by the use of poisoning is the reason for the spraying of pesticides, exposure to organic phosphorus pesticides, absorbed by the skin and inhalation Airborne pesticides caused by; life-threatening mainly due to misuse, self-service, misuse or intake of pesticides contaminated water and food caused.

Organic Phosphorus pesticides through the gastrointestinal tract, respiratory tract, skin and mucous membrane after the rapid distribution of the body organs, including the highest intrahepatic concentration, followed by kidney

General decomposition after the reduction of toxicity and toxicity after oxidation but enhanced. Organic Phosphorus pesticide excretion faster, 24h through the kidneys by urinary excretion, so the body is not accumulated.

Organic Phosphorus pesticides can inhibit many enzymes, but the toxicity of humans and animals mainly in the inhibition of cholinesterase. In vivo cholinesterase mainly exists in the central nervous system gray matter, red blood cells, autonomic nerve preganglionic fibers, postganglionic fibers and sports endplates, organophosphate into the human body, the rapid combination with the cholinesterase to form a stable Phosphorylated choline enzyme, easy to hydrolyze, thereby inhibiting cholinesterase activity, loss of the ability to break down acetylcholine, acetylcholine accumulation, causing acetylcholine as the mediator of the nerve, including sympathetic and parasympathetic ganglion fibers, parasympathetic ganglion Posterior fibers, a small amount of sympathetic ganglion fibers (such as sweat glands secrete nerves and striated muscle vasodilator nerves) and motor neurons are exaggerated symptoms. Cholinergic nerve excitability can be expressed as poisonous grass (m) and nicotine (n) symptoms. The choline receptors distributed in the tissues (heart, smooth muscle, glands, etc.) that are dominated by cholinergic ganglion fibers are called "virginine-sensitive choline receptors" or "m-choline receptors" The choline receptors in the synaptic and myelosomal endplates are called "nicotinic susceptible cholinergic receptors" or "ncholine receptors".

Cholinesterase is inhibited by Organic Phosphorus pesticides after rapid recovery in the nerve endings, partially inhibited by the chrome cholesteryl esterase in the second day has been basically restored; red blood cells of the cholesteryl esterase is suppressed after the general can not Self-recovery, to be a few months to red blood cells after regeneration of whole blood cholinesterase activity can be restored.

Long-term exposure to Organic Phosphorus pesticides, cholinesterase activity can be significantly reduced, and clinical symptoms are often lighter, may be due to the accumulation of acetylcholine on the body increased tolerance.

Organic phosphorus delayed neurotoxicity, latency more than 10 to 30 days, Organic Phosphorus pesticides to methamidophos as much, regardless of the severity of poisoning, regardless of acute poisoning or chronic poisoning can occur, the toxic mechanism and organic phosphorus gall Alkaline esterase inhibition has nothing to do, but the organic phosphorus on the peripheral nerve and muscle fiber direct toxicity of the results.


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