Organic phosphorus on humans and animals is mainly on the inhibition of acetylcholinesterase, causing acetylcholine accumulation, the cholinergic nerve by persistent impulses, leading to the first after the failure of a series of muscarinic, nicotine-like and central nervous system symptoms ; Severe patients may be due to coma and respiratory failure and death, Organic Phosphorus insecticide mostly oily or crystalline, color from light yellow to brown, slightly volatile, and garlic. In addition to trichlorfon, the general difficult to dissolve in water, not easy to dissolve in a variety of organic solvents, in alkaline conditions easily decomposed failure. Commonly used dosage forms are emulsions, oils and powders. R and R 'are alkyl, aryl, hydroxylamine or other genes, X is alkoxy, propyl or other substituents, and Y is oxygen or sulfur.
Organic phosphorus on the human body is the main harm, it will be combined with the body of acetylcholine ester, so that acetylcholine can not be water decomposition. Light, blurred, headache, dizziness, fatigue, tears, salivation, abdominal pain, vomiting, chest tightness, nausea, boredom uncomfortable, sweating, diarrhea or mild movement disorders. Severe cases may lead to miosis, difficulty breathing, muscle fibrillation or fatigue, systemic cramps, blurred consciousness, disappearance of the pupil reaction or coma, pulmonary edema, incontinence, etc., and finally due to tracheal contraction, respiratory secretions too much, diaphragm Contraction of fatigue, causing respiratory failure and death of the central nervous system.
The severity of Organic Phosphorus poisoning is related to the types of Organic Phosphorus, the dose of poisoning, the body's absorption of toxicants and the rate of exclusion. In general, in addition to a small number of Organic Phosphorus pesticides (such as Fenxinsong) slow symptoms, most of the poison in a few minutes to twelve hours, there will be symptoms, poisoning after treatment without death, Occurred in six hours. Poisoning and early detection and do the appropriate treatment, often in the acute phase after the rehabilitation, so appropriate to prevent and emergency treatment is very important.