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Symptoms Of Organic Phosphorus Poisoning In Dogs
Jul 04, 2017

In life, most dogs have the habit of eating things, may be curious, may be hungry, it may be nutritional deficiencies. And there are a lot of things that are toxic or toxic to dogs, but it can not be resolved. In this case, if you do not let your dog come into contact with or late it should not eat something, it is likely to lead to poisoning.

In life, most dogs have the habit of eating things, may be curious, may be hungry, it may be nutritional deficiencies. And there are a lot of things that are toxic or toxic to dogs, but it can not be resolved. In this case, if you do not let your dog come into contact with or late it should not eat something, it is likely to lead to poisoning. And organic phosphorus poisoning is a class. The so-called Organic Phosphorus poisoning is: refers to organic phosphorus containing toxic substances through direct skin contact, respiratory inhalation and misuse, misuse lead to body poisoning. Serious patients can die due to coma and respiratory failure.

Pathogenesis:

Organic phosphorus (or Organic Phosphorus pesticides) into the body, the main inhibition of cholinesterase activity. Acetylcholine released from the cholinergic nerve endings (acetylcholine is a neurodehmate, transmission of information between synapses), under the action of cholinesterase. The Organic Phosphorus compounds can be combined with cholinesterase to form acylated choline, and acylation choline is stable, only extremely slow hydrolysis can occur, and for a long time may also be irreversible. And can not restore its decomposition of the role of acetylcholine, resulting in a large number of acetylcholine synaptic aggregation, the phenomenon of excessive excitement of cholinergic nerve.

Symptoms:

Organic Phosphorus poisoning is due to the chemical properties of its preparations, animal species, and the specific circumstances of the different symptoms and the degree of its expression is also very different. But all belong to the cholinergic nerve by acetylcholine over-stimulation of the symptoms, clinically can be divided into three categories:

1, muscarinic-like symptoms (M-like symptoms): parasympathetic ganglia before and section fibers, and distributed in the sweat gland of the sympathetic ganglia fibers such as cholinergic nerve excitement, can be expressed as: loss of appetite, salivation, vomiting, Diarrhea, sweating, urinary incontinence, miosis, visual mucosa pale, dyspnea, increased bronchial secretions and pulmonary edema.

2, nicotine-like symptoms (N-like symptoms): when the body by the nicotine-like role, can cause rhabdoid muscle motor nerve endings and sympathetic ganglion fibers such as cholinergic nerve excitement. But in the accumulation of acetylcholine is too much when the paralysis. Specific performance: muscle fiber tremor, blood pressure, muscle tension decreased (especially the respiratory muscle), pulse frequency and so on.

3, the central nervous system symptoms: This is the animal brain tissue choline enzyme inhibition, the excitement between the central nervous cells reached an obstacle, resulting in central nervous system dysfunction, the performance of the sick animal excitement, body temperature Elevated, twitching and even coma.


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