The toxicity of Organic Phosphorus to humans and animals is mainly on the inhibition of acetylcholinesterase, causing acetylcholine accumulation, the cholinergic nerve by persistent impulses, leading to the first after the failure of a series of muscarinic, nicotine-like and central nervous system symptom.
Severe patients can be due to coma and respiratory failure and death, organic phosphorus mostly oily or crystalline, color from light yellow to brown, slightly volatile, and garlic. In addition to trichlorfon, the general difficult to dissolve in water, not easy to dissolve in a variety of organic solvents, under alkaline conditions easily decomposed failure. Commonly used formulations are emulsions, oils and powders.
Acute poisoning can be divided into three levels: ① mild poisoning: a dizziness, headache, nausea, vomiting, sweating, chest tightness, blurred vision, weakness, miosis. ② moderate poisoning: In addition to the above symptoms, there are muscle fiber fibrillation, pupil was significantly reduced, mild dyspnea, salivation, abdominal pain, abdominal, gait staggering, clear consciousness. ③ severe poisoning: In addition to the above symptoms, and coma, pulmonary edema, respiratory paralysis, brain edema.
Acute poisoning generally no sequelae. Another patient in the acute re-poisoning symptoms disappeared 2 - 3 weeks after the occurrence of delayed neuropathy, mainly involving the limb end, and can occur lower limb paralysis, limb muscle atrophy and other neurological symptoms. The current permit for this disease is not caused by inhibition of cholinesterase, probably due to organic phosphorus insecticide inhibition of nerve target esterase (NTE, formerly known as neurotoxinase) and its aging.
In the acute poisoning symptoms and delayed onset of neuropathy before, usually in the acute poisoning after 24-96d sudden death, called "intermediate type syndrome" F 浞 ⒉ "Parker? The function of the postsynaptic at the muscular joint. Before death can first neck, upper limbs and respiratory muscle paralysis, upper limbs and respiratory muscle paralysis. Involving cranial nerves, the emergence of ptosis, ocular abduction disorders and facial paralysis.